With a series-opening victory over Alabama A&M on Friday, the Devilettes put together back-to-back wins for the first time in 2019.
Mississippi Valley State got seven innings of work from Alyssa Montes, who picked her fourth win of the season.
A&M got on the board in the first inning, but MVSU (6-29) answered in the with a sac fly from Sharia Cormier.
It was the second SWAC win of the year for MVSU.